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For expected values [8] of sensitivity and specificity at 85 and 75%, respectively, a desired level of precision set at 10% and the prevalence of delirium set at 50%, the number of patient inclusions required for achieving appropriate power would be 95.
We found that the formation of these ubiquitin-containing inclusions required K63 of ubiquitin, which has been previously linked to clearance of ubiquitinated proteins by the authophagy pathway [30], [31].
Therefore, we tested whether the effect of HSJ1a on Parkin inclusions required these domains (Fig. 2).
For example, the discovery of TDP-43 in ubiquitin-positive intraneuronal inclusions required the generation of ∼1000 monoclonal antibodies, which were used to screen thousands of tissue sections by immunohistochemistry, to obtain a single monoclonal antibody that specifically labeled ubiquitin-positive intraneuronal inclusions (Neumann et al., 2006).
Similar(56)
Not every issue ended up as a plank in the party's new manifesto -- inclusion required approval by two-thirds of the delegates, a difficult threshold.
He has set up a ministry of "development and social inclusion", required that native groups be consulted on extractive projects and raised mining taxes.
Inclusion required Norwegian languages skills.
Inclusion required either ST depression or cardiac biomarker elevation.
Pre inclusion required the ability to read and write French.
Study inclusion required informed consent.
Furthermore, inclusion required a Karnofsky Index (KI) ≥70% without high anesthetic risk.
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CEO of Professional Science Editing for Scientists @ prosciediting.com