This has been observed previously with the chaperones HDJ-1 (DNAJB1), HDJ-2 (DNAJA1), HSC70 (HSPA8), α-SGT and β-SGT (Hay et al., 2004) and raises the intriguing possibility that cytoplasmic inclusions adopt a conformation or composition that is unfavourable for recognition and binding by chaperones, or that chaperone decorated cytoplasmic inclusions are rapidly removed by autophagy.
First of all, as a result of the strict inclusion criteria adopted, our sample included a very small number of metastases (only five), preventing the inclusion of this category in the statistical analyses.
Due to the discontinuity of the on-off input, Filippov's differential inclusion is adopted to describe the dynamics of trajectories of the closed-loop system.
There's a lot of work to be done, not only between now and May, but ongoing until a full nationwide policy of inclusion is adopted.
More stringent inclusion criteria adopted in our study, including higher levels of baseline neutrophil and platelet, may also contribute to the negligible haematological toxicity in our cohort.
Main inclusion criteria adopted for patient selection included availability of primary breast cancer tumour tissue, possibility to verify the response according to RECIST criteria, and availability of clinical data including survival.
Additionally, the exclusion of some international studies[ 62- 64] due to the inclusion criteria adopted could be seen as a limitation of the review in its goal to reflect the research made in Spain on HRQL in Breast Cancer patients.
The inclusion criteria adopted for this study is the strictest reported so far and should permit a rigorous assessment of the role of prepubertal duration on the development of diabetes complications.
The inclusion criteria adopted for the study included consenting out patients diagnosed and confirmed to be HIV positive, at least 18 years of age and had been on HAART for 3 months.
The inclusion criteria adopted (surgical patients expected to require invasive mechanical ventilation for more than 48 hours), however, selected a homogeneous population of ICU patients, treated by the same staff adopting the same protocols to prevent infection - assuring, in our opinion, consistent and reliable results.
