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One reason to think that it is not effective is that the list of fallacies is not complete, and that even if the group of core fallacies was extended to incorporate other fallacies we thought worth including, we could still not be sure that we had a complete prophylactic against bad arguments.
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However, with the 4000 SNPs included, we could only assess the marginal contribution of adding SNPs in the pathway.
Because the parameter for screening number was included, we could not extrapolate beyond the 4 screenings that was the maximum number of screenings per subject in our data.
First, only online English articles in scientific journals were included; we could have missed studies in other languages, grey literature or hardcopies only.
Moreover, since we had information about diagnoses as well as service demands of the patients included, we could show which diagnoses and medical services were associated with both definitions of frequent attenders.
Even if they were included, we could detect the affected lacrimal glands as a nodal pattern on sonograms, as abnormal F-FDG accumulation on FDG-PET/CT, and as abnormal swelling on CT and MRI.
Of the seven cytokines included, we could indeed verify that the serum protein level of both CXCL9 and CXCL10 were significantly modulated in COPD patients, irrespective of their FFMI, compared to healthy controls (Additional file 10).
We could've included more, we could've included less.
However, by including SYN, we could contrast between distractors related to the target words and distractors related to the context (to be more specific, collocation).
Including adenomas, we could show that the MSI status differs between tumours within each individual.
Without including this we could not generalize any of the conclusions beyond the effect one a single prey item.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com