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Ten patients, including three Phase I patients, had excessive toxicity consisting of grade 3 stomatitis plus grade 3 4 haematologic toxicity (four), myelosuppression that required successive dose reductions (three), a decrease in LVEF to 45% (one), interstitial pneumonitis (one) or grade 3 asthenia plus severe infection (one), which led to premature interruption of therapy.
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The pit formation process is demonstrated in Fig. 6, including three phases: elastic deformation, plastic deformation, and climbing over the pile-up.
Subsequently, the forming process of the pit is analyzed in detail, including three phases: elastic deformation, plastic deformation, and climbing over the pile-up.
Subsequently, ten studies, including six phase 2 studies, used the FMI formulation.
The efficacy of DAC in high-risk MDS patients was demonstrated in several clinical studies, including two phase III studies.
The contours of an alternative approach, including five phases, are shown in Figure 2.
In the PRECEDE-PROCEED model, a thorough needs assessment including five phases should be made before planning a health promotion intervention.
The development process, including four phases, was iterative and comprehensive, using the biopsychosocial model and the approach presented by the SCT as guidance.
MRC proposed a new procedure for introducing and evaluating complex clinical interventions including five phases: theory, modeling, exploratory trial, definitive randomised trial and long-term implementation.
The current project includes three phases over the next three years.
The operation of SPSA PSO includes three phases.
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CEO of Professional Science Editing for Scientists @ prosciediting.com