Sentence examples for including potency from inspiring English sources

Optimization for several parameters including potency in the presence of human plasma, selectivity against CYP3A4 inhibition and improved rat oral bioavailability led to the identification of 8d which demonstrated antihypertensive efficacy in a transgenic rat model of human hypertension.

These marked differences noted above were concordantly observed with higher biological activity of some of the Synthon EU FOGA lots compared with Copaxone lots, including potency and cytotoxicity activities as well as gene expression of pathways that regulate apoptosis, IL-2, and inflammation signaling.

The cannabis packaging will also need to contain a host of information including potency, weight, packaging date, and number of units or doses.

A number of different criteria have been proposed for the selection of genetic inhibitors for advancement to human clinical trials, including potency of inhibition, lack of immunogenicity, lack of toxicity, and the propensity for evolution of resistant viruses [5], [6].

The second is focused on elements of hormone action including "potency", "endpoints", "timing", "dose" and "thresholds".

A 'lead' compound is designated when a series of criteria (including potency, selectivity, synthetic access, 'drug-like' properties [see later] and potential for further optimisation) are met.

Model parameters included potency and rate constants for loss of pharmacodynamic effect by hydrolysis dependent and independent processes.

It covers a large number of proteins and a large, diverse set of molecules, and a good portion of this data includes potency information.

Introduction of the spirocyclic pyranochromene scaffold yielded several advantages over previous generation cores, including increased potency, reduced efflux, and reduced CYP2D6 inhibition.

Hymenochirin-1Pa shows broad spectrum anti-bacterial activity, including high potency against multidrug-resistant clinical isolates of Staphylococcus aureus, Acinetobacter baumannii, and Stenotrophomonas maltophilia.

We selected a short list of Tox21 compounds for confirmation in orthogonal assays based upon original Tox21 HTS values including compound potency and efficacy, activity in viability assays, curve fit parameters that included the shape of concentration response curve, flags and sensitivity and selectivity of compounds to VDR.