Sentence examples for including mutations in the from inspiring English sources

Advance in our knowledge of the human genome has provided a comprehensive picture of commonly mutated genes in patients with HCC including mutations in the TERT promoter, CTNNB1, TP53 and ARID1A along with other amplifications (FGF19, VEGFA) or homozygous deletions (p16) as the most frequent alterations.

Some of Esmé's differences appear to stem from multiple genetic mutations, including mutations in the genes PCDH19 and SCN8A.

This could be attributed to several mechanisms including mutations in the viral genome, inhibition of the presentation and processing of certain epitopes, and/or the inability of the T cells to adequately respond to survival signals.

A mouse model of human HCC with inducible expression of MYC in adult liver cells has shown that overexpression of MYC is sufficient to initiate HCC development; however, these tumors develop with a prolonged latency, suggesting that other genetic alterations are necessary to generate HCC, including mutations in the p53 pathway [32], [37], [38], [39], [40].

This could have led to some changes in AMTN sequence, including mutations in the sequence encoding the RGD motif.

The original screen for Ctf clearly pointed to cohesion as the most mutable process including mutations in the cohesin subunits themselves (Table  1; Spencer et al. 1990).

Therefore, imatinib resistance in AR cells can be caused by complex and dynamic mechanisms, including mutation in the BCR/ABL1 gene.

These HR defects include mutations in the HR pathway genes RAD51C, RAD51D, and PALB2 (6–10%)7,9,10, as well as methylation of BRCA1 (7–17%)7,11,12 or RAD51C (1.5–3%) promoters11,13, which is generally mutually exclusive of BRCA1/2 mutation7,9,10.

These include mutations in the genes BRCA1 and BRCA2.

An example of a recently built data set which includes mutations in the context of imatinib, dasatinib, nilotinib and a newer drug bosutinib, can be found in [67].

Rarer causes of diazoxide responsive HH include mutations in the GCK or HADH genes (9, 10).