We identified 16 genes for which deletion or transcriptional repression enhanced echinocandin susceptibility, including components of the Pkc1-MAPK signaling cascade.
In the deduced evolutionary models, regulatory molecules, including components of the signal transduction pathways and transcription factors, are recruited from conserved pathways.
Candidate genes include PcG components and chromatin factors, as well as many protein-modifying enzymes, including components of the SUMOylation pathway.
NPs are similar in size to subcellular structures, including components of the mitotic spindle, permitting critical interactions with these subcellular structures that are not possible with larger particulates.
Localized mRNAs encode a variety of proteins types including components of the cytoskeleton, transcription factors, regulators of translation, and even secreted signaling molecules [1].
SpeB is known to cleave numerous host proteins including components of the extracellular matrix, cytokine precursors, immunoglobulins and antimicrobial peptides [11] [13], which could interfere with host immune functions.
CyaB, and a cAMP-dependent transcriptional regulator, Vfr, regulate the expression of over 200 genes, including components of the T3SS, TM, the T2SS, flagellar motility, and quorum sensing [12].
The insertion and deletion of hundreds of uridines leads to the formation of functional mRNAs for mitochondrial proteins including components of the major mitochondrial respiratory complexes and the ATP synthase.
Frataxin has been proposed to be a multifunctional protein based on its numerous interactions, including components of the Fe-S biosynthesis machinery, ferrochelatase, mitochondrial aconitase, succinate dehydrogenase, and several chaperones [2], [9] [12], [15].
The expression of the enzyme is increased in metacyclic promastigotes and it may be a ligand involved in the interaction of the parasite with defensive systems of the host, including components of the complement system and the macrophage surface.
P. aeruginosa produces several virulence factors associated with acute infection, including components of the Type IV pilus (TFP), Type III secretion system (T3SS), Type II secretion system (T2SS), and quorum sensing systems (reviewed in [2]).
