Given the unexpected extent of structural variation among individuals, it is very likely that there is an important contribution of such variants to phenotypic differences, including predisposition to common and complex disorders.
Interestingly, the clinical profile of CIPA does not include predisposition to cancer.
The mechanisms by which CKD causes CVD outcomes are still not fully elucidated, but may include predisposition to early atherosclerosis [ 4].
It is curious that 15% of guardians opted for secondary reporting for predictive genetic test results including predisposition and carrier status for their children, despite the unavailability of these results to minors.
Consistent with contraindications for bupropion use, exclusion criteria included predisposition to seizures, a diagnosis of bulimia or anorexia nervosa in the past year, an unstable medical or psychiatric illness, alcohol dependency within the last year, or a myocardial infarction in the last month.
BRCA2 changes have also been related to other aggregations of malignancy, which include predispositions to ovarian, pancreatic or skin tumours (BCLC, 1999).
Furthermore, the complexity of the unique biology of this affective disorder, which includes the predisposition to episodic and often progressive mood disturbance, and the dynamic nature of compensatory processes in the brain, coupled with limitations in experimental design, have hindered our progress to date.
Individuals with germline mutations in the Shh receptor PTCH have Gorlin syndrome, which includes a predisposition to medulloblastoma [ 3, 47].
The etiology of OFD is varied and includes genetic predisposition, injury to the central nervous system (CNS), peripheral trauma, medications, metabolic or toxic states, and neurodegenerative disease.
* Possible causes of asexuality include genetic predisposition, hormonal imbalance or childhood experiences.
