This analysis indicated that both HERV-K and RhERV-K had similar demographic histories, including markedly smaller effective population sizes, compared to CERV-K.
Histological analysis demonstrated typical morphologic features associated with the basal-like subtype, including markedly elevated geographic tumor necrosis, ribbon-like architecture associated with central necrosis, pushing margin of invasion, and stromal lymphocytic response in tumors from PyVT/ADN mice [43] (Figure 4B).
The renal protection is evident from histopathologic observations including markedly reduced tubular cast formation and fibrosis in the kidney.
Severe acute hepatitis, liver failure, and end-stage liver disease are associated with marked abnormalities in screening tests, including markedly elevated PT/APTT and very low fibrinogen levels.
In this study, we demonstrated several beneficial effects of tau reduction in a mouse model of Dravet syndrome, including markedly reduced occurrence of sudden death and epileptic manifestations and significant improvements in cognitive and behavioral performance.
Following pIpC treatment of adult mice, heterozygous mice developed a PV-like phenotype, including markedly increased haemoglobin, haematocrit, red blood cells, leukocytosis, thrombocytosis, splenomegaly, reduced serum erythropoietin (Epo) levels and Epo-independent erythroid colonies.
Transcriptome assembly has "many informatics challenges" [ 5] including markedly different expression levels of genes and homeologues, as well as potentially high levels of sequence similarity between duplicated gene copies (for homeologues and other paralogues).
Autopsy findings included markedly enlarged hemorrhagic mediastinal lymph nodes on gross examination and laboratory detection of B. anthracis by immunohistochemical tests in mediastinal lymph nodes, spleen, liver sinusoids, and phagocytic cells.
In rats, RUPP pressure between days 14 and 19 of pregnancy induces a full pre-eclampsia pregnancy phenotype, including markedly elevated BP and changes in renal artery flow and glomerular filtration rate [ 50].
