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The CF phenotype also includes effects on gastrointestinal motility [ 28].
Thus far, rapid glucocorticoid action has been intensively investigated mainly in the central nervous system, and includes effects on neuronal excitability, neuroendocrine responses and behavioural tasks [ 90].
In other words, genetic effects on behavior do not stop at the skin genetic effects need to be considered in relation to an 'extended phenotype' that includes effects on individuals' environments (Dawkins 1982, 2004).
Whether the genetic basis of the cancer cell's phenotype is generated by mutation or by infection, the extended phenotype includes effects on extracellular components, as well as on normal, cancerous, and precancerous cells in the microenvironment.
This includes effects on cell proliferation [ 15], differentiation [ 9, 10, 16] and function [ 17], most notably in fat, where the enzyme appears to be a key facet of adipocyte differentiation [ 13, 14] and insulin sensitivity [ 18].
This includes effects on the dissociation of NF-κB from its inhibitor IκB (which requires oxidation), the regulation of IκB degradation, and the binding of NF-κB to DNA (which requires a reducing environment).
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To inform decision-making, we conduct cost-effectiveness analyses of varicella vaccination, including effects on HZ.
Secondary aims include effects on functional outcome, pain, complications, quality of life, and cost-effectiveness.
The chemicals the E.P.A. is planning to test, mostly pesticides, have already been thoroughly characterized for toxicity, including effects on reproduction.
The report last week argues that the U.N.'s estimates "were produced too quickly" and failed to include a variety of cost multipliers, including effects on the energy, manufacturing and retailing sectors, ecosystem protection and increased storm intensity in coastal areas.
The ecological or environmental impacts include effects on the ecosystem, human health, and natural resources [2].
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