The state's data also show that the company's most frequent violations were in the most serious category, including deficient brake systems, steering or suspension components and emergency exits.
Other problem areas frequently encountered include deficient medical record keep and lack of adherence to the standards for postgraduate education.
Alcohol consumption during pregnancy can result in fetal alcohol spectrum disorder (FASD), a constellation of disabilities including deficient pre- and postnatal growth, morphological malformations of the face and/or brain, and cognitive and behavioral deficits [1].
Our previous studies demonstrated that hypomorphic Sp4 mutant mice, in which expression of the Sp4 gene is reduced to 2% 5% of the level in wildtype mice, displayed a variety of behavioral abnormalities including deficient sensorimotor gating [4].
This procedure induces various behavioral deficits in tests used in schizophrenia models, including deficient prepulse inhibition and hyperresponsivity to amphetamine, as well as neurodevelopmental alterations, as described below.
The reduced efficacy of ONYX-015 given systemically could be the result of a number factors including deficient adenovirus receptor expression, extensive removal of virus by hepatic up-take, and effects of the immune system despite the impaired immunity.
These mice have compromised responses to an array of immune functions, including deficient germinal center formation and immunoglobulin isotype class switching, reduced delayed hypersensitivity responses, and reduced helper cell differentiation.
The mechanisms of bone effects considered secondary to kidney damage include deficient reabsorption of calcium in the renal tubuli and compromised activation of vitamin D in the renal cortex.
One example is the problem of defining normal G6PD activity, which typically is described as the mean or median activity for a given population including deficient and heterozygous values.
LS patients typically develop sudden onset of severe brain stem dysfunction, psychomotor regression, hypotonia, ataxia, and lactic acidosis during their infancy or early childhood and display various types of biochemical defects, including deficient oxidative phosphorylation (2).
