Several strategies to produce live attenuated tetravalent vaccines are being pursued including attenuation of viruses by conventional passage in tissue culture or introduction of defined attenuating mutations into recombinant DEN viruses [ 6- 9].
These properties include attenuation of inflammatory responses in the lung, mucoregulatory properties, and effects on bronchial responsiveness.
Direct action of the antibody is premised on receptor downregulation and subsequent alterations to intracellular signaling including attenuation of downstream pro-tumorigenic cell signaling, inhibition of HER2 shedding, and inhibition of tumor angiogenesis.
TGF-β1 in neuropathy may include attenuation of spinal neuroinflammation, attenuation, or upregulation of glutamate transporter downregulation, and a decrease of spinal extracellular excitatory amino acids.
Functions of NO in muscle include: attenuation of muscle force generation and regulation of appropriate blood and oxygen delivery to active muscles during exercise [1], [3] [7].
Reported cardioprotective effects of metformin include attenuation of myocardial infarct size and improved left ventricular function.
NMBAs are also thought to have an anti-inflammatory effect, including attenuation of inter-leukin-6 and 8 expression [ 6].
Although data are still conflicting [ 49], beneficial effects of beta blockers were reported to also include attenuation of an overshooting immune response.
Statins, known for their lipid-lowering capacities, have a variety of pleiotropic properties including attenuation of inflammation through anti-atherogenic and antioxidant actions.
