The DE proteome included known and novel mineralization regulators, including matrix metalloproteinase 20 (MMP-20), 5′ nucleotidase (NT5E), and secreted phosphoprotein 24 (SPP-24 or SPP-2).
These predictions included known DTIs involving human enzymes, ion channels, G-protein-coupled receptors (GPCRs) and nuclear receptors, and also suggested potential novel DTIs [17].
A multivariable logistic regression model was constructed which included known confounding variables to assess for associations between maximum and minimum intraoperative heart rate and myocardial injury.
In rice, the most enriched domains among the interactors included known interaction domains PF00400 (WD40), PF00069 (protein kinase), PF00270 (DEAD), and PF02985 (HEAT).
The company went so far as to maintain two sets of safety books -- one that included known dangers, and another watered-down version that miners and inspectors could see, investigators said.
This identified 4 phenotypic classes of drug suppressors, which included known and novel genes.
The latter group included known PD proteins, PDLP1 [31], and AtBG_papp (At5g42100; [21]).
These included known L. japonicus salt-responsive metabolites such as serine, threonine and ononitol ([10]; Figure S2).
The DPA1*0103/DPB1*0201 binding data were obtained from Ref. [46] and included known epitopes as well as a set of overlapping peptides spanning Phleum pratense antigens.
Exclusion criteria included known allergy to any antimalarial drug or presence of acute or chronic, clinically significant pulmonary, cardiovascular, hepatic or renal disease.
The analysis of the genomic context revealed that only eleven of the clones identified by FACS included known promoters (Fig. 2).
