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We argue that a relevant measure in this case is the degree to which already known cell cycle regulators, both transcription factors and sequence motifs, are included in the combinations retrieved by the different methods.
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Combinations of devices usually offer greater protection than the sum of the SPFs of each device included in the combination.
Correlation between the selectivity of a combination of pharmacophore towards their dedicated NRs ligands (average recovery rate against all the others NRLiSt BDB datasets) and the number of pharmacophores included in the combination.
This selectivity is associated to three features: the number of ligands in the dataset used to generate the pharmacophores (Kendall's tau coefficient, p-value = 3.476e−8), the number of pharmacophores included in the combination for the considered dataset (Kendall's tau coefficient, p-value = 5.915e−5) and the active ligands over decoys ratio (Kendall's tau coefficient, p-value = 4.461e−11).
This selectivity was significantly correlated with the number of ligands in the dataset that was used to generate the pharmacophores (Kendall's tau coefficient, p-value = 3.476e−8, Additional file 1: Figure S4) and with the number of pharmacophores included in the combination for the considered dataset (Kendall's tau coefficient, p-value = 5.915e−5, Additional file 1: Figure S5).
Hence, the selectivity of the combination of pharmacophores against its dedicated NRs activity decreased for datasets with a large number of ligands (and consequently with a large number of pharmacophores included in the combination) or with a number of active ligands largely outnumbering the number of decoys.
Treatment of infections caused by CROs using a combination of two or three active drugs has consistently been associated with improved outcomes, with carbapenems being included in the combination when the minimal inhibitory concentration (MIC) of the pathogen against meropenem does not exceed 8 mg/L [51, 52].
If the smear microscopy was also included in the combination, it reached 100% sensitivity.
The mAbs included in the combination therapy should target distinct regions on the antigen with non overlapping epitopes and should be able to complement each other in a treatment regimen [13], [14].
Two trials in early-RA patients indicated a superior efficacy when corticosteroids, in a step-down approach, are included in the combination therapy.
MiR-923 expression was found not to improve the fit of the model and thus was not included in the combination.
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