Fifty-six patients (68%) were included with consent given by a legal representative, while 27 patients (32%) were considered able to provide their own informed consent after an assessment of their competence [ 26].
I believe that all of the ZX Spectrum games included or included as in-app purchases within the above referenced apps were included with written consent, where such consent is available but I will need to review the written records relating to some 200 games before making a more fully informed comment".
In terms of recovery, the patients included with surrogate consent had a worse functional prognosis (day 90 mRS ≥3: 57.6%, compared with 16.8% in patients having provided consent themselves; p < 0.0001) and a worse cognitive prognosis (day 90 MMS < 24: 15.4% and 4.8%, respectively; p < 0.002).
The patients and their next-of-kin were included with informed consent.
However, they were included with the consent of the senior author.
Children will indicate on the group information form (included with the consent form) the group (A or B) they would like to participate (Table 1).
The patients included with surrogate consent were likely to be older and more aphasic, with a pre-existing cognitive disorder and more severe stroke (relative to the patients having provided consent).
In addition, patient-oriented clinical research in acutely ill patients has encountered numerous challenges over the past decade, including issues with consent, study design, appropriate endpoints, protocolized care, and determining adverse events.
This article sets out essential requirements for the lawful conduct of adolescent research in South Africa including compliance with consent requirements, child protection laws, and processes for the ethical and regulatory approval of research.
Children could be included with their parents' consent.
Children could be included with parents' oral consent.
