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We chose to include this domain, but found that the word anchors that best described this question differed from those in other questions.
We have confirmed that the μ-homology domains of FCHo proteins bind Eps15 and Eps15-like proteins in pulldowns from HEK293 cells by extending the bait proteins to include this domain.
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However, the searched databases certainly included this domain and many of the big data themes could potentially be assigned to its papers.
Our results suggest that the isoform devoid of a MYND domain has stronger regulatory capacity than that including this domain.
Our results in Drosophila support the latter possibility, as the PHD isoform that lacks the MYND domain has stronger regulatory capacity than the isoform that includes this domain.
As this domain is known to be altered in MDD, a battery that includes this domain would be ideal.
The presence of Z-DNA binding domains in some sponge ADARs indicates an ancestral ADAR included this domain and it has been lost in multiple animal lineages.
Structures including this domain have been solved for the MATH-BTB protein SPOP [58], [60], as well as the BTB-Kelch proteins KLHL3, KLHL11, Gigaxonin (or KLHL16), and KBTBD4 [56], [58], [58].
By including this domain in our questionnaire, we can test whether participants expect their treatments would have short term benefits for back pain or would have more lasting benefits.
We included this domain in the instrument in the appendix since it was reflective of concerns expressed by the majority of patients during the focus group/semi-structured interviews and may be an important area of improvement with newer therapies.
Previous studies from our laboratory highlighted an auto-inhibitory action associated with a site included in this domain, i.e. the P295-T311 sequence.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com