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Challenges of WHIMS-Y include lower than expected and differential enrollment.
Limitations to our study include lower than expected patient recruitment, small numbers in two of the intervention sites, a relatively high loss to follow up (10%) which was higher in the intervention group and missing data for some of the secondary clinical endpoints.
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Global data, including lower-than-expected U.S. economic growth figures, have dented the optimism at the start of the year that the world economy was picking up.
But nearly half the improvement forecast for the coming decade is due to factors unrelated to the budget battles, including lower-than-expected health-care costs and a recovering economy, according to a Washington Post analysis of congressional budget data.
This decline was largely due to fee reductions and client asset allocation choices – including lower-than-expected money market funds.
All are projected to have median home sale price increases next year, thanks to a combination of factors including lower-than-average inventory levels, little price volatility and high job growth.
A report by the nonpartisan Congressional Budget Office (CBO) said insurance coverage would cost $964 billion from 2015 to 2024, $68 billion below its April 2014 projection, due to factors including lower than expected enrollment in federal and state insurance exchanges set up under the Affordable Care Act.
Such protective immunity may be one possible explanation for unexpected field observations during natural outbreaks of H5N1 HPAI virus, including lower than anticipated morbidity in poultry in Hong Kong [21] and wild birds in Germany despite the presence of several hundred thousand susceptible birds in the affected area [22].
Reasons included lower than expected referrals and proportion of eligible patients, and early deaths.
Slight discrepancies between our observations and the reported mutation frequencies for oncogenes included lower than expected mutation prevalences for beta-catenin (CTNNB1) and BRAF in pancreatic and colorectal tumours, respectively; and higher than the reported frequencies for NRAS in colorectal cancer.
Examining the distribution of expression levels for known vs. predicted microRNAs in each culture stage, we find that in ESC the predicted microRNAs include lower concentrations than the known populations but the distributions mostly overlap in NSC (Figure S5).
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