This 'splitting' approach permits a reduction in the number of patients included in a trial.
The WHO Trial Registration Data Set provides a minimum set of requirements it considers should be included in a trial register [9].
China requires that 200 to 300 Chinese patients be included in a trial [ 23].
When this can be ascertained before randomisation, these subjects should not be included in a trial [ 7].
The majority of the residents included in a trial had to be over the age of 60.
Eighty-eight postmenopausal women with RA aged between 45-65 years were included in a trial which has been described previously [ 23].
The weighting factors applied to pathology indicators of survival in the NPI are not optimal for a population included in a trial of screening.
18 Some people might wonder whether an economic evaluation should be included in a trial before we know whether the new treatment is more effective.
The aim of this study was to analyze the hemodynamic behavior of patients included in a trial of intensive alveolar recruitment after cardiac surgery.
The results highlight an advantage of the urinary proteome analysis: a small number of subjects included in a trial may be sufficient to reveal significant effects of drug treatment, based on a classifier that serves as a surrogate marker.
