These include impediments to organ fabrication, the limited resolution of printed features, the need for advanced bioprinting solutions to transition the technology bench to bedside, the necessity of new bioink development for rapid, safe and sustainable delivery of cells in a biomimetically organized microenvironment, and regulatory concerns to transform the technology into a product.
These include impediments to HER2-trastuzumab binding, signaling through alternative pathways, upregulation of signaling pathways downstream of HER2, and failure to elicit an appropriate immune response [ 6, 23].
Proposed HER2-resistance mechanisms include impediments to HER2-inhibitor binding, signaling through alternative pathways, upregulation of signaling pathways downstream of HER2, and failure to elicit an appropriate immune response.
Deciphering the roles of genes in human health and disease is a grand challenge for many reasons, including impediments to defining phenotypes, difficulties in identifying and quantifying environmental effects, technical problems in generating genotypic information, and the difficulties of studying humans [ 1].
The systemic impediments include both the legacy of racism and dramatic economic changes that have fallen with disproportionate severity on poor blacks.
These impediments include low copy number, heterogeneity, polydispersity, hydrophobicity, and intrinsic disorder.
Real-world impediments include the following: (1) imperfect compliance with hand hygiene procedures [ 36], (2) cross-contamination of HCW hands when HCWs touch their own contaminated clothing [ 16, 18], and (3) recontamination due to the touching of contaminated surfaces [ 15].
Policy impediments include tension between housing affordability and health investment that causes inefficient cost-shifting, privacy issues, unclear statutory authority, and resulting gaps in responsibility for housing, indoor air, and the built environment.
Impediments include religious proscriptions and cultural taboos against suicide, concerns about precipitation of familial stigma, awareness that life insurance companies may resist redemption of policies on suicide decedents, political pressure, threatened or actual litigation, and a paucity of psychological autopsies [ 8- 10].
Examples of such impediments include lack of time, high dispensing workload, shortage of pharmacy staff, lack of recognition of the pharmacy professional by other health care providers, lack of funds or a low financial incentive, and lack of employer's recognition about the pharmacist's role and responsibilities [ 26, 56– 56].
Obesity prevention has been difficult to implement and major impediments include power inequalities across various actors due to lack of engagement. A. Linden provides an informative analysis of the missing data generated as the unintended consequence of lack of patient (or service users) engagement in public health research.
