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Need to include dose information in a form understood by referrers and patients.
Standard developmental toxicology bioassays are designed to identify agents with the potential to induce adverse effects and include dose levels that induce maternal toxicity.
Approaches to further increase therapeutic efficacy of Fc-engineered intact antibodies with reduced half-lives can include dose fractionation [39], use in pretargeting radioimmunotherapy approaches [40] or combination with chemotherapy [28, 29].
Prognostic factors in accidental/staggered overdose include dose ingested and time from ingestion to presentation.
The protocol was amended to include dose levels 75 and 90 mg kg−1 later.
Common assumptions underlying dose investigation strategies include dose proportionality and similar exposure−response relationships in adults and children.
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Merck could also include doses of fifteen and twenty milligrams, for people who tried the starting dose and found it unhelpful.
These models include dose-dependent mechanistic hypotheses of toxicological interactions which can be tested by model-directed experimental design and used to identify dose regions where interactions are not significant.
Less commonly cited indications include dosing to decrease metabolic demand, control of intracranial pressure, and decrease agitation.
The New York state figures presented on the CDC's Web site did not include doses allocated for New York City.
Most common adverse effects of ganciclovir treatment include dose-dependent neutropenia and blood counts including absolute neutrophil count.
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