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Risk factors for the development of rifabutin-associated uveitis include dosage and duration of rifabutin therapy, low body weight, and use of concomitant medications, including clarithromycin and ritonavir [21].
This may include dosage intensification and the use of chemotherapeutic agents with alternative modes of action.
Some potential and practice-related questions that also remain include dosage and timing for testosterone replacement therapy to prevent PCa.
Strategies to attenuate drugs and radiation toxicity include dosage optimization, synthesis, and the use of analogues having lower toxicity or a combined therapy with antioxidants.
Prescribers' dosage instructions vary in quality, 4 and many prescriptions include dosage instructions that are not written directly for the patient's use.
The reasons for heterogeneity in treatment effects include dosage regimen, duration of therapy, trial quality, publication date and whether patients had septic shock or other forms of severe sepsis [ 153].
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The clinician treating patients with bipolar disorder should expect a level of nonadherence including dosage omissions, changes, and drug holidays, even among patients determined to recover.
The optimal adjusting mode by NaOH (including dosage and frequency) was evaluated according to indexes of pH, VFAs, NH4+-N, TS, VS, TS/VS, TS and VS removal rate.
This review provides a comprehensive and up-to-date analysis of oral dosage forms considering key aspects of formulation design including dosage considerations, ease of use, tolerability and safety, manufacturing complexity, stability, supply and cost.
Outside the controlled environment of clinical trials, several variables may affect the pharmacodynamics of a particular drug, including dosage, duration of use, indication, comorbidities, and use of concomitant medications.
Several factors play an important role in enhancing or diminishing the potential for AIDD including: dosage form properties, absorption and metabolism of ethanol, dilution of stomach fluids, and gastric emptying.
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