Moreover, we aim to include all compounds in advanced clinical trials, as this is highly relevant in the context of drug discovery.
We decided to include all compounds in further analysis, however, because doxycycline was shown recently to increase lifespan in animals fed with tetracycline-resistant bacteria and minocycline was found to increase lifespan in Drosophila melanogaster (Oxenkrug et al., 2012; Houtkooper et al., 2013), suggesting antibiotic-independent mechanisms for both compounds.
The list below does not include all compounded models but a large number of them and some new ones.
Conversely, the new set of validation compounds included all compounds for which we found new data from the sources mentioned, and is thus probably more heterogeneous than the first validation set, which had the same data source.
Then, for developing classification models, the developmental toxicity data set was divided in two classes, i.e. non developmental toxicant (N) and developmental toxicant (D), as indicated in Table 7. Class N merges the first two FDA categories A and B, and the class D includes all compounds belonging to categories C, D and X.
Tancrede et al. (1987) used personal VOC Total Exposure Assessment Methodology TEAMM) data for New Jersey to evaluate cancer risks and found a much elevated risk of 19,000 per million, mostly because the authors included all compounds in their cancer assessment, assigning a cancer potency value to compounds with no published values.
The ePlatton search results included all the compound-MET interactions in the first two most similar ligand clusters and other possible interacted proteins were KIT, KDR and FLT3 [for the detailed list, see Additional file 6].
Therefore, in this study DOC includes all the organic carbon compounds released by plastic, from truly dissolved substances to any polymeric nano-plastic that might have been also fragmented from the plastic surface.
In models that we could not include all fruit compounds together, we separated them into two different sets: one included 'non-energetic' compounds (fibre and proteins) and the other included 'highly energetic' compounds (sugars and lipids).
If the TOC emission rate is being calculated, Cij and Coj include all organic compounds measured minus methane and ethane; if the total organic regulated material emissions rate is being calculated, only organic regulated material are included.
The Earths' primordial soup may have been a complex mixture, but it likely did not include all of the compounds found today in even the simplest cells.
