Mrs Nicklinson and Mr Lamb have argued that the law should include a "defence of necessity".
Necessities include: a clean pair of socks, gym uniform, a separate pair of shoes for gym, deodorant or antiperspirant, and personal things.
The definition of the irradiation field is governed by several factors that illustrate the necessity to include a proportion of normal tissues: possible tumor extensions undetected by medical imaging techniques, uncertainty concerning patient positioning reproducibility between each fraction, and the mobility of tumor and healthy organs during and between each fraction.
In conclusion, the study demonstrates the high diversity of gene expression profiles associated with melanoma, the necessity to include a sufficient number of samples regarding clinical standards, for the design of standardized sample collecting and preparation, for the development of common standards for microarray data processing, and for developing standardized bioinformatic tools.
Implications for experimental design of animal studies of developmental exposures to neurotoxicants include the necessity of a 'no behavioral experience' group, given that epigenetic changes in response to behavioral testing can confound effects of the neurotoxicant itself.
Other recent instances of this kind of mainstreaming include the necessity of a Tennessee federal court's order mandating the final inspection of a controversial mosque after a lengthy delay and the appointment of former Army Lt. Gen William Boykin, a fierce critic of Muslims, to the post of executive vice president of the Family Research Council.
The results also underline the necessity to include a wide variety of geological conceptual models and not to restrain parameter space exploration within each concept as long as no field data allows for conceptual model or parameter value falsification.
Our study illustrates the necessity to include a large number of patients in genetic case-control studies.
Limitations of the study include the necessity of using a partial ecological design in order to include Aboriginal ethnicity and socio-economic status for which data is unavailable at the case level due to privacy constraints.
Lessons from ZAMFOHR's organizational development include the necessity of selecting a multi-stakeholder and -sectoral Board of Directors; performing comprehensive situation analyses to understand not only the prevailing research-and-policy dynamics but a precise operational niche; and selecting a leader that bridges the worlds of research and policy.
