Genomic disorders constitute a class of diseases that are associated with DNA rearrangements resulting from region-specific genome instability, that is, genome architecture incites genome instability.
Our results refine the critical region for Potocki-Lupski syndrome, provide information to assist in clinical diagnosis and management, and lend further support for the concept that genomic architecture incites genomic instability.
The concept of genomic disorders is predicated on two general ideas: firstly, that genomic disorders occur by rearrangements of our genome (the human genome is disordered) and not by DNA-sequence-based changes (that is, not by base-pair changes or by SNPs that cause disease); and secondly, that genome architecture incites genome instability.
Furthermore, other mechanisms, such as nonhomologous end joining and retrotransposition, can lead to structural variation that results in genomic disorders [ 140], and unique genome architectural features other than LCR/SD, such as AT-rich palindromes [ 141, 142] and non-B DNA conformations [ 86, 143], can incite genome instability.
9.37pm BST Putin then called on Kiev to implement a ceasefire, but blamed Putin then blamed "radical, nationalist, often even neo-fascist, fundamental forces, [including in] Ukraine now" for inciting violence and instability.
Instead of tanks and troops, and top-down repression a la Tiananmen Square the new oppressors of democratisation are the Basij, the "pro-government protesters," the plainclothes security personnel, the agents provocateurs inciting violence and instability.
Page A4 TENSIONS RISE IN SUDAN The Sudanese government has filed a complaint with the United Nations Security Council that South Sudan, its newly independent neighbor and former territory, is inciting violence and instability in the Nuba Mountains of Sudan, a volatile border area where U.N. officials warn that war crimes may have been committed in recent months.
KAMPALA, Uganda — The Sudanese government has filed a complaint with the Security Council that South Sudan, its newly independent neighbor and former territory, is inciting violence and instability in the Nuba Mountains region of Sudan, a volatile border area where United Nations officials warn that war crimes may have been committed in recent months.
According to the official news agency, "The statement added that the Ambassador, under the cover of visiting some hospitals, also met with some people in the same framework of inciting more violence and instability and in attempt to sabotage the ongoing national dialogue and deepen discord and sedition among the Syrian people who strongly reject and condemn such foreign instigation".
The nonrenewable nature of fossil fuels, the co-production of greenhouse gas, particulate, and heavy metal emissions during combustion, and the political instability incited by dependence on non-domestic energy sources demand a more sustainable approach to energy development.
Despite the low sea surface temperatures, the instability incited by cold atmospheric air within a baroclinic zone regions with high differences in temperature and pressure permits the formation of medicanes, in contrast to tropical areas lacking high baroclinity, where raised SSTs are needed.
