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As previously reported (8, 10), a significant treatment group effect was found for all measures of incident neuropathy at DCCT closeout favoring intensive treatment compared with conventional treatment (P < 0.001).
This possibility was addressed using analytic models of incident neuropathy that adjusted for nerve conduction study results at DCCT closeout.
Analytic models of incident neuropathy that adjusted for differences in NCS results at DCCT closeout showed no significant risk reduction associated with former intensive treatment during follow-up (odds ratio 1.17 [95% CI 0.84 1.63]).
Analyses show that former intensive therapy had a long-term effect on incident confirmed clinical neuropathy among subjects free of this outcome at DCCT closeout (supplemental Table 5a).
During EDIC, there was a 31% reduction in the risk for incident CAN in INT subjects who were free of CAN at DCCT closeout, with significant risk reductions remaining after adjustments that included age, R-R variation at DCCT closeout, medication use, and several other covariates (Table 4) (9, 16).
In additional models that adjusted for the average rank of selected NCS results at DCCT closeout, the former intensive treatment group no longer showed a significant effect on incident neuropathy during the EDIC study.
Although models that adjusted for NCS differences at DCCT closeout based on a composite NCS score failed to show significant treatment group differences for incident neuropathy, we found support for the concept of metabolic memory on the NCS measures when we used more powerful analyses that adjusted for the actual NCS values at closeout.
For example, the OR for confirmed clinical neuropathy was 1.17 (0.84–1.63), indicating that the long-term difference in incident neuropathy observed during the EDIC study was explained by these subclinical differences in NCS results at DCCT closeout among subjects who did not have confirmed clinical neuropathy.
The shop became a closeout outlet.
It's Closeout Central, an off-brand oasis.
"What incident?
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