Nevertheless, 10%% of pregnancies still end before 37 weeks across the world and this high incidence of PTB is problematic because premature babies are at higher risk for lifelong health and developmental problems [ 2, 3].
Estimation of the true incidence of PJI is problematic, due to the inherent difficulties in making an unquestionable diagnosis of a PJI due to the lack of a universally accepted definition, as described in several papers and reviews (Bauer et al. 2006, Della Valle et al. 2010, Parvizi et al. 2011a).
The present study is an attempt to take the definition of problematic use incidence further by incorporating a proportion of individuals that used heroin who never show up in the main source under study (usually treatment).
This incidence can be referred to as "problematic use incidence" and its trend could provide a satisfactory overview of problematic heroin use, assuming a constant proportion over total incidence.
A problematic high incidence of infection and erosion problems has been reported in some studies, which can hopefully be improved with a more stringent sterile protocol and centralization of the procedure to select specialist centers.
Additionally, while both studies show an increase in risk for subsequent disease among household contacts, directly comparing the risk to the incidence of primary invasive disease is problematic (25 ).
Conclusions: Although limited by small sample size, REVIVE provides valuable information on the incidence of recurrent VTE, major bleeding and problematic issues associated with therapy of VTE in children.
In particular, the incidence of catheter-associated thrombosis has proven problematic in recent trials of sodium citrate locks [ 26].
Many CNVs are presumably heterozygous in these lines, which is problematic because the incidence of CNVs may be underestimated.
The VEE VRP vaccine vectors are particularly attractive because the VEE envelope glycoproteins target the VRP to cells of lymphoid tissue [ 40], because they can be administered multiple times [ 39], because they induce both cellular and humoral immune responses, and because pre-existing immunity to VEE in humans should not be problematic since the incidence of VEE infection is low.
