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The incidence of node involvement was 10% at level III and 6.4% at level IIa.
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The incidence of node-positive patients in the training and validation sets was 46.2 and 73.3%, respectively.
Patients with ER-positive tumors who were also positive for PIK3CA mutation had a higher incidence of node-negative disease (53% versus 22%; P = 0.025).
However, in correlation analysis, nodal stage was associated with PIK3CA mutation status only for those in exon 9, with patients harboring an exon 9 mutation having an increased incidence of node-negative disease (66.7%) compared with patients with wild-type or other mutation types (24.8%; P = 0.023).
However, in a Gynecologic Oncology Group GOGG) study published by Stehman et al., an unexpectedly high incidence of groin node recurrence following superficial groin node dissection was found [ 50, 51].
INH α over-expression in PC3 significantly increased the incidence of lymph node tumours (P=0.0341) and lymph node tumour size (P=0.0047) compared to the EV-transfected clones.
Furthermore, INH α over-expression in LNCaP cells did not change the incidence of lymph node metastasis or the size of the lymph node tumours.
But mucosal gastric cancer, which has a higher incidence of lymph node metastasis, should be treated by gastrectomy with lymph node dissection.
All efforts should be made to adapt and delineate the CTV according to the location of the primary tumor and the relative incidence of lymph node involvement in the different anatomic regions of the lymph nodes.
A direct relationship was found between local extent and size of the tumour and between local extent and the incidence of lymph node metastasis, but not between tumour size and the incidence of lymph node metastasis.
In contrast, only 5 out of 12 lymph nodes of control animals revealed human cells, suggesting an increased incidence of lymph node invasion in mice with wt TP53 reexpression at this stage of tumour progression.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com