Loss of Ce HCF-1 protein at reduced temperatures (e.g., 12°C), however, leads to a high incidence of embryonic lethality and early embryonic mitotic and cytokinetic defects reminiscent of mammalian cell-division defects upon loss of HCF-1 function.
Mice lacking SAFB1 exhibit developmental abnormalities in their lungs, high incidence of perinatal lethality, and adults develop different types of tumors.
At the physiological level, depletion of Safb1 activity in mice lead to developmental abnormalities in their lungs, high incidence of perinatal lethality, and dwarfism [ 26].
This combination resulted in higher frequencies of the monocotyledonous phenotype but also in other severe pattern effects as well as a high incidence of embryo lethality.
The introduction of the GS(2 SC1 line in this background, significantly reduced primary eye tumour size and caused a high incidence of adult lethality.
Placement of the Tigm Gga2 allele into the C57BL6/Ola129Sv mixed background results in a lower incidence of neonatal lethality, showing the importance of genetic background in determining the requirement for GGA2 during this period.
Although mobilization of the Dupuy variant was more efficient, allowing the transposons to spread wider and to different chromosomes, this system suffered from a high incidence of embryonic lethality and a strong predispostion to haematopoietic tumours.
A high incidence of embryonic lethality (60 80%) and X-chromosome nondisjunction (∼10- to 20-fold higher than in the wild type) is observed in lin-41 (tn1487 ts ) mutants at a semipermissive temperature (22°) and in several of its intragenic revertants at 25°.
Heat shock treated embryos over-expressing or lacking menin are characterized by a high incidence of apoptosis and lethality [16].
Deterioration of immune function and an increased incidence and lethality of infectious diseases caused by Candida albicans have been observed in tumor patients [ 16, 17].
This study has revealed a high incidence and lethality of early neonatal infections, emergence of severe infections in non-pregnant adults and an increase of bloodstream and urinary tract infections.
