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Finally, given the observational and cross-sectional nature of our data and the relatively low incidence of established disease, we are unable to determine the clinical significance and modifiability of the reported ORs.
In our second, large case-control sample for CAD/MI the incidence of established cardiovascular risk factors, such as male gender, type 2 diabetes, hypercholesterolemia, hypertension and smoking, as well as increased BMI, was higher in CAD/MI cases (n = 1,473) as compared to controls (n = 1,241) (Table 2).
Incidence of established SCD remains stable over an 8 year observation period.
We report for the first time a systematic and conservative assessment of incidence of established sudden cardiac death (SCD) in Germany resulting in 81 cases of SCD per 100 000 per year.
Whereas there is no effect on our primary objective to assess the incidence of established SCD cases, we cannot comment on the outcome of the subgroup of patients not transported to one of the district hospitals.
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Furthermore, IR has been shown to be an independent predictor of cardiovascular disease in T2DM [ 13] and predicted systolic HF incidence independently of established risk factors including diabetes in the community [ 14].
PARP-1 inhibition with 5-aminoisoquinolinone (AIQ) significantly reduces incidence and severity of established collagen-induced arthritis, completely abrogating joint swelling and destruction of cartilage and bone.
P-APRV appears to be an exciting and novel open lung strategy that may significantly reduce ARDS incidence, morbidity, and mortality of established ARDS.
This is due to its rising incidence and the persistent lack of established treatment guidelines.
Administration of vorinostat decreased tumour incidence and inhibited the growth of established mammary tumours (Cohen et al, 2002).
We identified EN-RAGE as a novel biomarker for incidence of coronary heart disease, independent of established risk factors and inflammatory markers, such as C-reactive protein [ 56].
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