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The extent to which other factors such as environment and customs may contribute to the high incidence of EC remains to be explored.
The three EC high-risk populations in this study appear to share a similar patrilineal genetic background that may explain, at least in part, the high incidence of EC in these areas in China.
The incidence of EC varies widely, and certain areas such as northern China [1], northeastern Iran [2], and South Africa [3] have very high rates of this disease, with age-standardized incidence rates from 50 to over 100 cases per 100,000 population per year.
For example, in a relatively isolated district within the CSP Nanao Island annual average crude incidence of EC was 103.98/100,000 people from 1995 to 2004; the age-standardized incidence rates for EC were 72∼150/100,000 males and 26∼64/100,000 females, with a significantly increased incidence for males, but not females between 1995 and 2004 [5].
The incidence of EC has markedly increased in recent years.
Information on date and cause of death was collected for those who died, as was information of incidence of EC.
Similar(47)
The overall average annual incidence of EC-BSI was 52 per 100,000 population, and increased from 42 to 60 per 100,000 population over the study period.
We found that the overall incidence of EC-BSI in our setting (52 per 100,000 population) was higher than that reported from studies in similar developed countries.
The incidence of EC-BSI was higher that that described from other developed countries, with significant demographic variation, most notably in ethnic-specific incidence rates.
Similar to other studies [ 5, 12, 24], we also observed an age-related difference in the incidence of EC-BSI, with the highest incidence in the very young and elderly age groups.
Unexpectedly, we found a difference in the incidence of EC-BSI across ethnicities, with rates highest in Pacific Peoples and Māori (83 and 62 per 100,000 population respectively).
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