Exact(24)
The incidence of dose reduction because of toxicity was low for both oxaliplatin and 5FU.
The incidence of dose reductions was similar in the subgroups of male and female patients.
This would be consistent with the higher incidence of dose delay in the patients carrying the variant allele.
A lower incidence of dose reduction was associated with the CYP2B6*9 allele (8% vs 2%, P=0.020).
The incidence of dose modifications (reductions or interruptions) due to any AE was also generally similar between age groups.
This increased toxicity is reflected in the increased incidence of dose reduction in those patients receiving cetuximab.
Similar(36)
The primary endpoint was the incidence of dose-limiting toxicities (DLTs).
Of all nonhematological toxicities, anemia showed the largest incidence of dose-limiting (grade >3) toxicities.
The primary end point was the incidence of dose-limiting toxicities (DLTs).
Dose escalation to motesanib 125 mg QD occurred if the incidence of dose-limiting toxicities (DLTs, primary endpoint) was ≤33 %.
The primary endpoint was the incidence of dose-limiting toxicities (DLTs; defined below); the secondary endpoint was determination of the pharmacokinetic profiles of motesanib and erlotinib.
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