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However, higher incidence of clusters between Z-lines (see Supplementary material online, Figure S4 ) and shorter distance between clusters in the longitudinal axis may have similar effects.
Patients with malignant hemispheric stroke similarly showed a high incidence of clusters of recurrent CSDs with prolonged high-frequency-ECoG depression (Dohmen et al., 2008).
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They showed that the incidence of non-clustered cases declined more dramatically than the incidence of clustered cases.
Our data show a significant decrease in the incidence of clustered TB cases from 1997 1999 to 2002 2004.
Among Spanish-born persons, the incidence of clustered and nonclustered cases declined significantly, reflecting a significant decrease in case rate.
The actual incidence of clustering was compared to the incidence that would be expected by chance, by using space-time nearest-neighbor analysis.
Therefore, the decline in the incidence of clustering can indicate the impact of interventions aimed at reducing recent TB transmission (38).
However, one epidemiological study conducted in the UK reported 2.3 % English Springer Spaniels among 1260 dogs with epilepsy and reported a high incidence of cluster seizures [ 46].
The reduced incidence of clustered cases coincided with an increased number of TB cases among foreigners and likely indicates introduction of new strains of M. tuberculosis into the community.
BL designed and supervised the bioinformatic study, developed the initial framework for the analysis of the genomic sequences, made an independent observation about high incidence of clustering of super-conserved regions around genes encoding DNA-binding proteins, and annotated the UCR clusters with co-localizing genes.
Although severe clinical courses (high incidence of cluster seizures and status epilepticus) were frequently reported among Australian Shepherds, seizure remission was obtained in 12%% of dogs (6 % with and 6%% without antiepileptic treatment) [ 9], which is in line with remission rates reported in other canine epilepsy studies [ 8, 10, 11, 27].
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