Exact(7)
Mixed-effect logistic regression models were used to model the relationship between dose and ORR or neutropenia incidence (grade 2, 3, and 4 or grade 3 and 4).
Adjusted for sex, age, comorbidity, year of incidence, grade, stage and treatment, the multivariable RR for aspirin users compared with non-users was 0.77 (95%CI 0.63 0.95; P=0.015).
Multivariable models were build to adjust for sex, age, comorbidity, year of incidence, grade, stage, surgery, adjuvant chemotherapy for colon cancer patients and preoperative radiotherapy for rectal cancer patients.
Primary endpoint is the evidence of the safety and feasibility of the study treatment on the basis of incidence grade III and IV NCI-CTC-AE (v. 4.02) toxicity and/or the dropout of planned therapy due to any reason.
The most frequently reported (>10% incidence) grade 3 4 drug-related adverse events on the single gemcitabine arm were transaminitis (13.6%) and neutropenia (also 13.6%), whereas in the combination arm, lethargy, neutropenia, thrombocytopenia and transaminitis occurred in 28.6, 14.3, 11.9 and 11.9% of cases, respectively.
Primary aim is the assessment of the safety and feasibility of the study treatment on the basis of incidence grade III and IV NCI-CTC-AE (v. 4.02) toxicity and/or the dropout of the patient from the planned therapy due to any reason.
Similar(53)
The incidence of grade 3 and grade 4 diarrhea was 5.8%and1.9%9%, respectively.
The incidence of grade III and grade IV toxicities experienced by patients during treatment is given in Table 1.
The incidence of grade 2 or 3 neurotoxicity and grade 3 or 4 neutropenia was higher with cDC than with sDC (11.7% vs 8.5%; 36.8% vs 11.3%).
There was a low incidence of Grade 3/4 thrombocytopenia (two patients, 3%) and Grade 3/4 anaemia was not observed.
The incidence of grade 3 neutropenia is 3.1 % and no incidence of grade 4 neutropenia.
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