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However, the utility of the cross-sectional approach to HIV incidence determination has been hampered because currently available laboratory assays misclassify some chronically-infected persons as recently infected.
This sub-study was focused on the impact of pregnancy on the performance of the BED and avidity assays for cross-sectional HIV incidence determination.
While pregnancy does not generally influence the performance of serologic assays, the impact of pregnancy on the performance of serologic assays for HIV incidence determination has not been investigated.
Effective application of these assays to cross-sectional HIV incidence determination, either alone or in multi-assay algorithms, requires knowledge of the clinical and demographic factors associated with misclassification [12].
It should be noted that aside from assay misclassification, another critically important issue with cross-sectional HIV incidence determination is the whether the samples are representative of the population of interest.
However, studies suggest that these assays may be useful for HIV incidence determination when used in combination along with non-serologic biomarkers, such as HIV viral load or CD4 cell count [6].
Similar(51)
Although our study reports novel population incidence rates for Hafnia alvei isolation, there are a few methodological aspects of our incidence determinations that merit discussion.
In high TB incidence settings, determination of distinct transmission patterns is often indefinable, but may be greatly enhanced by the use of both molecular and conventional epidemiological tools.
Further studies are needed for evaluation of this phenomenon and determination for incidence.
Lack of data before 2001 meant that there could be no determination of incidence during that year.
Mice were infected with different S. aureus strains and were daily evaluated by a clinical follow-up that included weight determination, disease incidence and individual clinical scores.
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