Incidence is broadly estimated at 20 40% of travellers per month but varies by country or region visited, duration of travel and sociodemographic factors.
There were 34 (0.7% 95% CI, 0.5 1.0%) grade 5 DRAEs during the study; the overall incidence was broadly similar across age subgroups (0.4 1.0% Table 4).
The pattern of geographical variation in incidence correlates broadly with the worldwide distribution of Kaposi's sarcoma-associated herpesvirus (KSHV; human herpesvirus-8 (HHV-8)), which is considered to be a necessary cause of Kaposi's sarcoma (Chang et al, 1994, 1996; Gao et al, 1996; Simpson et al ; 1996; Boshoff, 1999).
This incidence figure is broadly compatible with pooled data from older studies [1], [4], and with more recent studies [5], [6].
All our calculated incidence rate ratios remained broadly similar when we additionally adjusted for other risk factors significantly associated with increased risk of venous thromboembolism (model 2).
In actual fact, even at the most superficial level, the incidence of cancer is broadly consistent with the action of natural selection acting against a detrimental pathology: prereproductive cancer is rare, while the incidence of postreproductive cancer is much higher.
The cancer mortality of Australian indigenous people is higher than non-indigenous people, but at the same time the reported incidence of cancer is broadly similar for both groups.
Figure 2 shows that FZD3 was induced by a factor of >4 in 6 of 9 sporadic adenomas and 12 of the 26 FAP specimens, suggesting a broadly similar incidence of Wnt response pathway re-organisation between the two groups.
The incidence of hoarseness was broadly comparable between the groups, but the severity of hoarseness on the first postoperative day was lower in the TOC group (p = 0.02, Table 4).
The incidence of metastatic disease was broadly similar for all treatment groups, but the extent of dissemination was greater in rats whose treatment included cyclophosphamide.
