This occurs, predominantly, through the concerted action of a class of enzymes called PHDs (prolyl hydroxylases) that catalyse prolyl hydroxylation of HIF-α subunits, which incessantly targets them for VHL (von Hippel Lindau protein -dependent 26S protein -dependentation [ 4].
"This was his genius as a journalist," Ingrams says of Cobbett, though he could be describing Foot, "to label the targets then belabour them incessantly, issue after issue - the borough-mongers, the tax-eaters, the fund-holders, the placemen, The Thing itself".
Blunkett, as education secretary, meddled incessantly, immersing teachers and pupils in cartloads of regulations, tests and targets.
Grimes for the most part has run a cautious campaign, incessantly touting a "jobs agenda," her Kentucky cultural roots as a horsewoman and target shooter, and ridiculing McConnell as out of touch, ineffective and hard-hearted.
While Meinong and Husserl wrote sentences which seem to go on forever, the polemics that Marty incessantly conducts make his works even less palatable than theirs for many a reader, especially since the targets of his polemics are in many cases authors who are either forgotten or known by less than a handful of specialists.
Oak toads chorused incessantly.
The telephone rang incessantly.
The phone rang incessantly.
The girls smoked incessantly.
"He watched it incessantly.
