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Associated to the metabolism of serine, D-serine hydrolase (4.3.1.18) was not annotated on K. lactis, which may indicate its incapacity to convert D-serine into pyruvate.
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This behavior was explained by the repression of de novo nucleotide synthesis by adenine, and the incapacity of amd1-mutant cells to convert this purine base into GXP nucleotides [ 46].
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