However, for the present drug targeting carrier systems, the target-selective delivery and release of loaded drugs are incapable to control completely.
In striking contrast to full-length PRELI, mutant PRELI/LEA− expression was completely incapable to uphold mitochondrial ΔΨm, induced by STS, TNF- α and UV radiation.
Some microorganisms, incapable of completely converting their carbon compounds to carbon dioxide, release energy by fermentation reactions, in which the intermediate compounds of catabolic routes either directly or indirectly accept or donate hydrogen atoms.
Then, because hRev1 is incapable of completely extending similar DNA substrates, hPolκ was subsequently added to extend the DNA products to full-length for HT-SOSA analysis.
Thus, in contrast to 2H-5, 2′-OMe-PS- CCG 12 is incapable of completely reversing an FXTAS-associated splicing defect.
The standard Differential GPS (DGPS) method is incapable of completely eliminating the ionospheric error.
As wastewater treatment plants (WWTP) are incapable of completely removing these compounds during the treatment process [6, 23 25], WWTP effluents constitute a major point source for benzotriazoles in the receiving rivers.
However, the NRR antibodies were incapable of completely inhibiting ligand-dependent Notch1 activation; whether this stems from masking of the binding epitope in a subset of receptors, residual intrinsic responsiveness of antibody-bound receptors, or some other mechanism remains to be determined.
Recently, Zeisel and colleagues generated betaine:homocysteine methyltransferase (BHMT) knockout mice that are incapable of completely catabolizing choline.
A fully modified 2′-OMethyl phosphorothioate is incapable of completely reversing an FXTAS-associated splicing defect and inhibits translation of the downstream ORF, which could have deleterious effects.
