This chimeric connexin is capable of forming gap junction-like structures at the cell surface but incapable of forming functional gap junction channels or functional hemichannels as revealed by dye [ 33] and electrical [ 43] coupling assays.
It quotes court-papers citing walls and windowsills containing enough lead to "poison the children and leave them incapable of leading functional lives".
In contrast, P2X6 subunits, which are incapable of forming functional homomeric channels in Xenopus oocytes, were retained in the ER as apparent tetramers and high molecular mass aggregates.
When exposed to Cre, the second exon of the VGLUT2 gene was deleted, rendering the Cre-infected neurons incapable of expressing functional protein and hence preventing vesicular neurotransmitter (glutamate) packaging and subsequent release of glutamate from rPCRt neurons [40].
We are still largely incapable of designing functional proteins de novo.
If TCR transgenic cells were incapable of fully functional stimulation and destined for some form of sub-optimal stimulation or death by neglect, one would predict diminished activation of Bclxl in the transgenic response.
Our data reveal that IL-11 is incapable of stimulating functional osteoclasts on bone slices, as shown by the lack of resorption pits on the IL-11 treated bone slices.
Thus, these results indicate that Cx26 is incapable of forming functional GJIC between NSCLC cells due to the defects in plasma membrane assembly, excluding the possible involvement of GJIC in the Cx26-mediated EMT and acquired gefitinib resistance in NSCLC cells.
"People aren't genetically incapable of working".
Our gene silencing results using both GFP and LacZ reporter assays suggested that the unFLOXed GRIM.miLacZoff vectors were incapable of producing mature, functional miLacZ sequences.
