Chris A. Norris, a mammalogist at the American Museum of Natural History, pointed out that urban squirrel populations tend to become physically isolated from the wild, and as they become increasingly more inbred, recessive characteristics are naturally seen in greater numbers.
An example for animal experiments is reporting the source, species, strain, sex, age, husbandry, inbred and strain characteristics, or transgenic animals, etc.
We thank the Jackson Laboratory and investigators (a detailed list of investigators of the mouse PHENOME projects is provided in the Text S1) for collecting and phenotyping inbred mouse strain characteristics.
The advantages of using mice include cost of housing, a short breeding period, the availability of inbred species with known characteristics, a well characterized immune system and genome, and the ability to either overexpress or delete specific genes, sometimes conditionally, that is, at specific times or in particular cells.
Sheep scrapie is caused by multiple prion strains, which have been classified on the basis of their biological characteristics in inbred mice.
Much research, based on transmission characteristics to inbred mice, has identified more than 15 classical scrapie isolates with distinct pathologies [ 12].
The Mouse Genome Database describes the origins and characteristics of inbred strains and is a comprehensive database for information about the mouse (www.informatics.jax.org).org
During the 4 h recovery subsequent to a 4 h sleep deprivation, old SAMP8 mice exhibit an enhanced sensitivity resulting in SWS (+62%) and PS (+120%) rebounds, a characteristic of this inbred strain.
White head spotting is a characteristic of the inbred CC founder strain WSB, and this phenotype was visibly present in 6 of the 110 nonalbino pre-CC mice.
The ITP protocol uses genetically heterogeneous mice to minimize the risk of confusion due to unique characteristics of single inbred or isogenic genotypes.
