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The regulation of hepcidin has clinical importance for patients with hemochromatosis and thalassemia, who exhibit inappropriately low levels of hepcidin despite the presence of iron overload[44] [46].
Immediately after surgery, anemia due to inappropriately low levels of erythropoietin or iron deficiency is common.
Elderly people with inappropriately low levels of fear of falling might take undue risks beyond their physical ability to cope.
At the same time, INDUS ensures that the abundant taxa proportions are not reduced to inappropriately low levels in scenarios wherein the query sequences originate from taxonomic clades having a high database representation.
Some decision-makers may place inappropriately low levels of trust in DS systems, due to fear of technology and automation, concern about the reliability of the overall system or its recommendations, or discomfort with black box methodologies [ 23, 24, 26].
5– 7 Patients with hereditary hemochromatosis 8 or thalassemia 9– 11 exhibit inappropriately low levels of hepcidin and increased intestinal iron absorption, despite the presence of systemic iron overload.
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In septic shock, however, a biphasic response has been recognized, with high levels in the early phase and inappropriately low AVP levels in established septic shock [ 1, 28, 29].
Consequently, hemochromatosis patients, who exhibit inappropriately low hepcidin levels, do not only suffer from iron overload, but also from increased rates of bacterial infections [2], [8].
This is reflected in the inappropriately low CRP levels at presentation.
Inappropriately low EPO levels persist for the duration of critical illness [ 3].
This model is supported by genetic data with BMP6−/− [ 19, 20] and liver-specific SMAD4−/− [ 21] mice, which develop iron overload and express inappropriately low hepcidin levels.
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