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Consequently, if the hypothesis of exclusively clonal propagation is accepted under a special assumption on A r (A r = 0 say, as is common usage) and if consideration of additional genetic traits reveals genetic variation within the supposed clone, then a Type one error is detected that is likely to be due to an inappropriate specification of A r.
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Inappropriate model specification can bias the results of an interrupted time series analysis and using a model that is not closely tailored to the intervention or testing multiple models increases the risk of false positives being detected.
Here we show that by confining MSCs to small islands, we can restrict inappropriate lineage specification and enhance the expression of mesenchymal stem cell markers Stro-1 and Endoglin.
The statistically significant diagonal values in the Cholesky matrix highlight correlation between attributes making an uncorrelated specification inappropriate (matrices for models with correlation available in Appendix A).
Software fault is an error situation of the software system that is caused by explicit and potential violation of security policies at runtime because of wrong specification and inappropriate development of configuration [2].
Author's response: Regarding the reviewer's statement concerning our specification of an "inappropriate TF model", we agree that is inappropriate but point out that this form was not used as a soft target.
Upon differentiation and lineage specification, HDACs cause lineage-inappropriate genes to be switched off by inducing a more compact chromatin configuration and resulting in a restricted gene expression repertoire.
Importantly, these Dlx1/ 2 double mutants exhibit incorrect specification of the LGE/CGE, with inappropriate expression of ventral cortex markers [ 110, 111].
Taken together, these data support a model in which Ezh2 -dependent H3K27me3 is required to repress specific sets of homeodomain-containing transcription factors in SVZ NSCs, preventing their inappropriate expression to potentially enable proper neuronal lineage specification.
The current design specifications for the CFST are generally inappropriate for circular CFAT beams under pure in-plane bending with high scatter of predictions.
Mutations in cell cycle-related genes has also been shown to affect the specification of daughter cell fate, as well as the inappropriate self-renewal of neural progenitors rather than differentiation [ 80].
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