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The "gene dosage" effect of Oct4 RNA injection may be due to enhanced Oct4 functions in transcriptional regulation, or Oct4 over-production may allow non-specific promoter-binding, or extra Oct4 causes inappropriate sequestration and subsequent inactivation of co-factors.
Thus, induction of CD69 expression by TLR ligand exposure may thereby result in inappropriate sequestration of activated CD8+ EM T cells in lymphoid tissue where they contribute to the lymphadenopathy [26] and inflammatory cytokine storm that characterizes HIV infection [24], [27].
This results in inappropriate sequestration of MGRN1 in cell culture systems, and might contribute to late-onset neuronal dysfunction and disease, similar to homozygous loss of MGRN1 function leading to late-onset spongiform neurodegeneration in mice.
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As revealed by structural studies performed by Huber and colleagues [ 10, 11], the potentially catastrophic elimination of inappropriate substrates is prevented by sequestration of active sites within the hollow structure of the 20S proteasome.
Using both published and new unpublished geological and historical data from Europe we critically review this model, show how it is inappropriate for the European context, and examine the implications for carbon sequestration and Riverine Ecosystem Services RESS) including river rewilding.
Now they bemoan sequestration.
WHAT is sequestration?
Sequestration is law.
For instance, carbon sequestration.
But sequestration happened anyway.
"Sequestration," Lew responded.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com