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Inappropriate sequence generation and inadequate allocation concealment can result in overestimates of treatment effects.
However, no difference in treatment effects in trials with appropriate or inappropriate sequence generation was found.
From the 393 trials included in the 43 meta-analyses, 156 trials (39.7%) had appropriate sequence generation and 237 (60.3%) had inappropriate sequence generation (229 were classified as 'unclear' and 8 as 'high' risk of bias) according to the Cochrane Collaboration guidelines.
Similar(57)
Thus, synergy is not always the rule and some antagonistic effects may result from inappropriate sequences between anti-EGFR drugs and cytotoxic agents as recently stressed by Davies et al (2006).
In addition, the present study brings particular focus to the importance of the combination sequence: it is shown that synergy is not a rule and that some antagonistic effects may result from inappropriate sequences, e.g. where ZD1839 is applied after the cytotoxic drugs (Table 4).
Even when an AP is given concurrent transmission opportunities, it may lose the chances due to the inappropriate frame sequence in its queue.
There was no difference in ES in trials with appropriate or inappropriate random sequence generation (ES=0.02; 95% CI −0.12 to 0.15).
These include inappropriate random sequence generation, 3 inadequate allocation concealment, 4 5 lack of blinding, 6 single centre status, 7 8 and the use of composite outcomes.
However, there are no standard implantation sequences for two-level ACDR using the Prestige-LP disc, and complications due to inappropriate implantation sequences remain unknown.
While we provide the evolutionary rate profiles (under M2a) for all the domains in EvoDB, the caveat is that calculation of d N/d S may be inappropriate for sequences that may have become highly diverged, say over millions of years or for closely related sequences.
Use of inappropriate pulse sequences will inevitably invalidate the results of a study [ 57].
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CEO of Professional Science Editing for Scientists @ prosciediting.com