Sentence examples for inappropriate repression from inspiring English sources

This is plausible in light of findings that in daf-2 mutants, dauer-stage genes are inappropriately expressed in non-dauers [46]; presumably inappropriate repression of non-dauer-stage genes also occurs.

These data suggest that epigenetic mechanisms participate in the inappropriate repression of miR-200c/miR-141 expressinn in cancer cells.

Thus, we propose that mutations in the transcription factors themselves or alterations to the developmentally regulated signalling pathways that modulate their activity contribute to the inappropriate repression of BRCA1 expression.

The repression of Miz1 target genes by Miz1/c-Myc and by Miz1/BCL6 complexes is important in physiological apoptotic responses [ 35] and in B-cell development [ 48] respectively; however, the inappropriate repression of cell-cycle inhibitors contributes to deregulated proliferation in tumours associated with the overexpression of c-Myc [ 51, 52] or BCL6 [ 48].

These changes have been associated with the inappropriate de-repression of several 4q35 genes, among which DUX4 is currently the leading FSHD candidate (Gabellini et al., 2002; Lemmers et al., 2010).

Other consequences that result from epigenetic changes, such as inappropriate expression or repression of some genes in the wrong cellular context, can also result in the alteration of control and physiological systems such that a normal cell becomes tumorigenic.

Are there other pathways of repression that repress inappropriate tissue-specific genes, or are the 'inappropriate' tissue-specific genes simply silent because the right combination of transcription factors are missing?

These genes encode the archetypal epigenetic marker proteins responsible for repression of inappropriate genes in differentiated cells [60].

Inappropriate temporal and spatial repression of MHC genes by overexpressed MeCP2 might induce defects in neuronal functions similar to those observed in β2m/TAP1 deficient mice [41].

As many of these genes are key developmental regulators, the current model holds that PcG protein-mediated repression prevents inappropriate differentiation.

In short, it is the balance between transcription of lineage appropriate genes and repression of inappropriate genes that allows progression through development.