Sentence examples for inappropriate production from inspiring English sources

Excess ACTH may result from pituitary tumours (Cushing disease), as in Cushing's first group of symptomatic patients, or from inappropriate production of the hormone by other tissues that do not ordinarily make ACTH (ectopic corticotropin syndrome).

Inappropriate production of the iron-regulatory hormone hepcidin contributes to the pathogenesis of common iron disorders.

Biological effects in wild freshwater fish that have been attributed to the effects of endocrine disruptors include the inappropriate production of the blood protein vitellogenin, altered growth and development (Vos et al. 2000).

The free radical theory states that the appropriate and inappropriate production of oxidants is intricately connected to aging and lifespan.

While pro-inflammatory cytokines are critical to combat pathogens, excess or inappropriate production of pro-inflammatory cytokines has serious consequences including tissue damage and septic shock.

Inappropriate production of TNF has been implicated in the pathogenesis of a variety of human diseases, including sepsis, cerebral malaria, diabetes, cancer, osteoporosis, allograft rejection, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel diseases [8], [9].

Although the cause of anemia in heart failure is unclear, the weight of evidence suggests that renal dysfunction, along with neurohormonal and proinflammatory cytokine activation in heart failure, favors the development of anemia of chronic disease, with defective iron utilization, inappropriate erythropoietin production, and depressed bone marrow function.

ELISA and cytometric assays on RBL2H3 cells demonstrate that the interacting peptides are able to displace the binding of IgE to receptor, confirming affinity and specificity of these ligands and suggesting a potential application as modulators of disorders associated with inappropriate IgE production.

A mutant TR from a patient with RTH exerted dominant negative activity by blocking the histone modifications induced by T3 on the TSHα promoter and likely contributes to the inappropriate TSH production observed in RTH.

Inappropriate cytokine production could create a tumour-promoting microenvironment in this cancer type.

Inappropriate SIMA production was detected by either anti-SIMA MAb 4D3 or 4A1, even in 85% of early stage cancers.