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This may be due to negative selection of such a sequence motif because it could mediate inappropriate interaction with SH2-containing proteins that is harmful in mammalian cells.
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In patients with inflammatory bowel diseases, the mucosal immune system has inappropriate interactions with the intestinal microbiota.
One of the questions surrounding the sex-abuse case against Jerry Sandusky is why a former district attorney chose not to prosecute the then-Penn State assistant coach in 1998 after reports surfaced that he had inappropriate interactions with a boy.
Finally, we found that the binding pockets of AR and MR are too small to accommodate UPA, and allowed us to propose that the extremely low sensitivity of MR to UPA is due to inappropriate interactions with the C11 substituent.
In recent months, we found out that my co-founder Dave McClure had inappropriate interactions with women in the tech community.
Examples reported in other groups included licensors demanding providers' attention to review charts or respond to questions while children needed comfort or attention and what respondents viewed as inappropriate interactions with children by the licensors or inspectors.
Her nagging dissatisfaction sneaks up on her in the form of psychosomatic finger-paralysis, inexplicable crying jags, and inappropriate interactions with nine-year old boys, door-to-door salesmen and auto mechanics.
John Lasseter's decision to leave Pixar and Walt Disney Animation Studios for six months following complaints of inappropriate interactions with employees has stunned the animation community and raised questions about the fallout for Disney's signature animation business.
This measure accounts for certain flaws in other nestedness estimates that have inappropriate interactions with matrix properties such as size and shape.
The latter event prevents inappropriate interactions with cellular proteins and non-specific binding by the signal recognition particle and consequent targeting to the ER [26], [35].
Indeed, certain misfolded cytosolic proteins have been shown to engage in inappropriate interactions with cytosolically oriented components of the ERAD machinery, thereby inhibiting retrotranslocation and activating the UPR [ 36, 37].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com