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The hereditary deficiency of antithrombin III, protein C, protein S, and plasminogen can be associated with a thrombotic tendency i.e., the inappropriate formation of clots in vessels.
However, inappropriate formation of fibrin clots may result in arterial and venous thrombotic disorders that may progress to life-threatening adverse events.
'Inappropriate' formation, and aggregation, of DPR might therefore confer neurotoxicity and influence clinical phenotype.
'Inappropriate' formation, and aggregation, of DPR may therefore confer neurotoxicity and influence clinical phenotype.
In the physiological milieu, a counterbalancing inhibition is required to prevent inappropriate formation of insoluble crystals of calcium salt [ 17, 18].
Further, inappropriate formation of dsRNA in introns could result in instability and degradation of those transcripts through the action of dsRNA-binding proteins and dsRNA nucleases.
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This pathway architecture underlies the spatiotemporal control of Atg1 kinase activity, thereby preventing inappropriate autophagosome formation.
Iron-sulfur clusters ([Fe S]) are important prosthetic groups of iron-sulfur proteins involved in numerous vital biological processes, such as respiration, photosynthesis and nitrogen fixation, and inappropriate cluster formation has detrimental consequences in both prokaryotes and eukaryotes [1].
We therefore concluded that inappropriate DSB formation on replicating chromosomes contributes to the loss of cell viability in checkpoint mutants.
α-Lactalbumin is limiting for lactose synthesis so the very low gene expression during pregnancy prevents inappropriate lactose formation.
With FVIIa use, the potential complications of pathological and inappropriate thrombus formation is present but thought to be low.
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