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Treatment failure with inappropriate dosing is of particular concern for pathogens with a high minimum inhibitory concentration (MIC) [14, 49].
UFH (unfractionated heparin) and protamine are integral to cardiac surgery, and inappropriate dosing can predispose to coagulopathy and hemorrhage.
Systematic research on equianalgesic opioid dose calculation is recommended to avoid adverse public health consequences of incorrect or inappropriate dosing.
Fully susceptible tuberculosis (TB) develops secondary drug resistance during therapy due to inappropriate dosing of treatment drugs, inadequate treatment, non-adherence to the prescribed regimen or using low quality medication.
Conclusions: Based on the results of this study,the main observed drawbacks were inappropriate dosing regimen,especially not considering loading dose in life threatening infections, inappropriate maintenance dose, and continuation of colistin, which has to be revised in order to achieve an effective treatment.
Manufacturing irregularities, improper drug reconstitution, and inappropriate dosing were ruled out as possible causes of PDSS.
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Thus, the agency said, children often receive inappropriate doses, or they get older, less effective medicines.
In some cases, overdoses and deaths have occurred when parents or guardians have given cough or cold medications to very small children in inappropriate doses.
The production of conventional antibiotics has increased to achieve victory over the multidrug resistance of Staphylococcus aureus and Staphylococcus epidermidis but intake of inappropriate doses and incomplete dose by patients has negated the effort.
Among the latter, 40 were excluded: 15 had received aminoglycosides in the previous seven days; 15 had received an inappropriate dose of amikacin; and 10 had an incorrect C max measurement taken.
The exclusion criteria were: treatment with amikacin within 7 days prior to inclusion; inappropriate dose of amikacin (<27.5 or >32.5 mg/kg); inappropriate duration of amikacin infusion (<25 or >35 min); and inappropriate delays in measuring the amikacin C max (<20 or >40 min after the end of infusion).
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