This could reflect major folding defects that result in the exposure of inappropriate domains and, hence, cause non-specific protein aggregation.
The presence of an inappropriate biosensor domain (i.e. a sequence not complementary to the substrate) resulted in a cleavage level comparable to that of the original ribozyme (Figure 1C, lane 5).
It determines that the statistics associated with the current EP PD50 test are inappropriate given our domain knowledge, but that the OIE test statistics are satisfactory.
As difficult as it is to defend strict or thoroughgoing Evidentialism, it is even harder to defend the view that Evidentialism is inappropriate in every domain.
Privacy can refer to a sphere separate from government, a domain inappropriate for governmental interference, forbidden views and knowledge, solitude, or restricted access, to list just a few.
According to the indices of GFI, NFI, CFI and RMSEA, the 3-factor measurement model fitted the current data moderately well, indicating inappropriate operationalisation of domain variables and need of further modifications of the measurement model.
These focus on locating highly concentrated 'peaks', and are inappropriate for identifying domains of dispersed histone modification marks (Pepke et al., 2009).
One objection to this sort of view is that judgements of responsibility are inappropriate in the cognitive domain.
Infallibilism with respect to either domain is inappropriate, but it is especially so with respect to the second.[33] In some passages Cavendish speaks of God to say that He is inconceivable and inexpressible.
This function is essential as it regulates spatial separation of permissive and non-permissive domains preventing inappropriate gene expression during latency and it may promote the co-ordinated cascade of gene expression during reactivation.
Also, because of our definition of high-risk medications as a list of drugs, the further domains of inappropriate prescribing such as underuse of medications and drug drug interaction might be missed.
